The Vitamin D Receptor

  19. Januar 2023, von Sebastian

The calciferol receptor (VDR) is a trans-acting transcriptional regulatory factor. It is actually expressed in the intestines, kidneys, skin, skeletal tissue, and a variety of immune cells. VDRs have been considered like a potential device by which vitamin D influences calcium supplement absorption inside the gut, cell division, and bone cells maintenance.

Inside the nucleus, the VDR is normally phosphorylated in serine elements by a number of protein kinases. When ligand binding develops, the molecule triggers multiple intracellular signaling pathways which might be independent of the focus on gene transcription process.

The vitamin D receptor is a member of the superfamily of trans-acting transcriptional regulating factors. It has a zinc finger DNA-binding domain, a ligand-binding website url, and a transcriptional account activation sector. These elements are required for the protein’s functional activity.

The cDNA corresponding to the vitamin D receptor was isolated coming from a human intestinal cDNA selection. RNA bare hybridization for the cDNA shown a single RNA species of about 4. six kb.

VDR expression is found in many cell types which include epithelial cells, glial fibrillary acidic healthy proteins, dendritic cells, platelets, neutrophils, macrophages, and oligodendrocytes. Research using confocal microscopy have shown VDR nuclear staining in several cellular cultures.

Some research have investigated the effects of VDR variants on osteoporosis and BMD. Yet , these research have been limited in their test size and get inconclusive.

Meta-analyses of hereditary association research have also proven heterogeneity. This may be a result of concealed stratification of the populations learned.


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